The unique characteristics of our RmSab™ may account for the improved quality of the antibodies produced in rabbits. The high specificity of Rabbit Monoclonal Antibodies has clear edges in assays.
Typically, Rabbit Monoclonal Antibodies have 10 – 100 times higher affinity than mouse monoclonal antibodies. On average, the KD values of Rabbit Monoclonal Antibodies range from 10-10 up to 10-12M.
Increased assay accuracy with decreased false positive rate.
Ideal choice for various application especially in IHC.
Lot-to-lot consistency due to recombinant technology.
Rabbit IgG has extra disulfide bonds in the variable region of the heavy chain. An extra disulfide bond also exists between Vκ and Cκ. These extra disulfide bonds may result in the great stability and long shelf life of rabbit antibodies.
Rabbit antigen presenting cells (APC) can present a broader range of epitopes than their mouse counterparts. Rabbits are able to generate high affinity antibodies against difficult epitopes, such as protein modifications, enzyme cleavage sites, or conformational epitopes as well as many less abundant proteins.
Rabbit antibodies recognize a greater diversity of epitopes per antigen compared to murine species. Rabbit monoclonal antibodies can detect antigens at the picomolar range with high specificity and provide higher signal intensity in a wide range of applications.Though strict screening and validation, we can provide antibodies in various requirements including some functional applications.
Due to production by cell culture.
