• Product NameMeclizine dihydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.
• Target NameHistamine Receptor antagonist
• CAS No. 1104-22-9
• Calculated MW 463.87
• Formulation C25H27ClN22HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.Cl.CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
  Pathways:GPCR/G Protein; Immunology/Inflammation; Neuroscience
  Receptor:H1 receptor
  Boling pt:495.3C
  Melting pt:
  Solubility:DMSO: 1 mg/mL (2.15 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. King CT, et al. J Pharmacol Exp Ther, 1965, 147, 391-398.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting