• Product NameAtopaxar
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAtopaxar is a reversible protease activated receptor (PAR)-1 thrombin receptor antagonist that interferes with platelet signaling. The effects of PAR-1 antagonists on biomarkers remain unknown. The primary objective was to assess the effects of atopaxar on biomarkers of inflammation and platelet activation.
• Target NameProtease-activated Receptor agonist
• CAS No. 751475-53-3
• Calculated MW 527.63
• Formulation C29H38FN3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CCOC1=C(OCC)C(F)=C2C(=N)N(CC(=O)C3=CC(=C(OC)C(=C3)N3CCOCC3)C(C)(C)C)CC2=C1
  Pathways:GPCR/G Protein
  Receptor:PAR-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting