• Product NameTH287 hydrochloride
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityTH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
• Target NameMTH1 inhibitor
• CAS No. 1609960-30-6
• Calculated MW 305.59
• Formulation C11H10Cl2N4HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CNC1=NC(N)=NC(=C1)C1=C(Cl)C(Cl)=CC=C1
  Pathways:DNA Damage/DNA Repair
  Receptor:MTH1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 10 mg/mL warmed (37.15 mM); DMSO: 53 mg/mL (196.93 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting