• Product NameCEP-32496
• Brief DescriptionInhibitors
• Purification95.78%
• Biological ActivityCEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.
• Target NameBcr-Abl inhibitor; c-Kit inhibitor; c-RET inhibitor; PDGFR inhibitor; Src inhibitor
• CAS No. 1188910-76-0
• Calculated MW 517.46
• Formulation C24H22F3N5O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(OC3=CC=CC(NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F)=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:Abl1; c-Kit; RET; PDGFRβ; Lck
  Boling pt:
  Melting pt:
  Solubility:DMSO: 9 mg/mL (17.39 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rowbottom MW, et al. J Med Chem, 2012, 55(3), 1082-1105.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting