• Product NameAEE788
• Brief DescriptionInhibitors
• Purification100.00%
• Biological ActivityAEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
• Target NameBcr-Abl inhibitor; c-Fms inhibitor; EGFR inhibitor; FLT inhibitor
• CAS No. 497839-62-0
• Calculated MW 440.58
• Formulation C27H32N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[C@H](C)C5=CC=CC=C5
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; JAK/STAT signaling
  Receptor:c-Abl; c-Fms; EGFR; HER2/ErbB2; FLT1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (199.73 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Traxler P, et al. Y Res, 2004, 64(14), 4931-4941.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting