• Product NameSC-514
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivitySC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
• Target NameAurora Kinase inhibitor; CDK inhibitor; IκB/IKK inhibitor; p38 MAPK inhibitor; Serine Protease inhibitor
• CAS No. 354812-17-2
• Calculated MW 224.3
• Formulation C9H8N2OS2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:NC(=O)C1=C(N)C=C(S1)C1=CSC=C1
  Pathways:Cell Cycle/Checkpoint; MAPK; NF-κb; Proteases/Proteasome; Chromatin/Epigenetic
  Receptor:Aurora B; CDK2/CyclinA; IKK2; p38α; PRAK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 45 mg/mL (200.62 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kishore N, et al. J Biol Chem, 2003, 278(35), 32861-32871.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting