• Product NameABT-199 (GDC-0199)
• Brief DescriptionInhibitors
• Purification99.92%
• Biological ActivityVenetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3.
• Target NameBCL inhibitor; Bcr-Abl inhibitor
• CAS No. 1257044-40-8
• Calculated MW 868.44
• Formulation C45H50ClN7O7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1(C)CCC(CN2CCN(CC2)C2=CC(OC3=CN=C4NC=CC4=C3)=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(NCC3CCOCC3)C=C2)[N+]([O-])=O)=C(C1)C1=CC=C(Cl)C=C1
  Pathways:Angiogenesis; Apoptosis; Cytoskeletal Signaling
  Receptor:Mcl-1; Bcl-2; Bcl-w; Bcl-xL
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL warmed (115.14 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Souers AJ, et al. Nat Med, 2013, 19(2), 202-208.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting