• Product NameI-BET151 (GSK1210151A)
• Brief DescriptionInhibitors
• Purification98.86%
• Biological ActivityI-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM in cell-free assays, respectively.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1300031-49-5
• Calculated MW 415.44
• Formulation C23H21N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC
  Pathways:Chromatin/Epigenetic
  Receptor:BRD2; BRD3; BRD4
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 27 mg/mL (64.99 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dawson MA, et al. Nature, 2011, 478(7370), 529-533.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting