• Product NameLY2109761
• Brief DescriptionInhibitors
• Purification99.83%
• Biological ActivityLY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
• Target NameTGF-beta/Smad inhibitor
• CAS No. 700874-71-1
• Calculated MW 441.52
• Formulation C26H27N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C(CN1CCOCC1)OC1=CC2=NC=CC(C3=C4CCCN4N=C3C3=CC=CC=N3)=C2C=C1
  Pathways:Stem Cells
  Receptor:TβRI; TβRII
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (4.52 mM)
  Appearance:Taupe Solid Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Melisi D, et al. Mol Y Ther, 2008, 7(4), 829-840.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting