• Product NameOF-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityOF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor with Kd values of 100 nM/500 nM for BRPF1B/BRPF2; 39-fold selectivity over BRD4.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 919973-83-4
• Calculated MW 440.31
• Formulation C17H18BrN3O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(NS(=O)(=O)C2=C(C)C=C(Br)C=C2)C=C2N(C)C(=O)N(C)C2=C1
  Pathways:Chromatin/Epigenetic
  Receptor:BRPF1B; BRPF2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 76 mg/mL warmed (172.6 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Structural Genomics Consortium (SGC).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting