• Product NameJNJ-7777120
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityJNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
• Target NameHistamine Receptor antagonist
• CAS No. 459168-41-3
• Calculated MW 277.75
• Formulation C14H16ClN3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1CCN(CC1)C(=O)C1=CC2=C(N1)C=CC(Cl)=C2
  Pathways:GPCR/G Protein; Immunology/Inflammation; Neuroscience
  Receptor:H4 receptor
  Boling pt:477C
  Melting pt:
  Solubility:Ethanol: 8 mg/mL (28.8 mM); DMSO: 56 mg/mL (201.62 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Jablonowski JA, et al. J Med Chem, 2003, 46(19), 3957-3960. 2. Thurmond RL, et al. J Pharmacol Exp Ther, 2004, 309(1), 404-413.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting