• Product NameGW 4064
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line.
• Target NameFXR agonist
• CAS No. 278779-30-9
• Calculated MW 542.84
• Formulation C28H22Cl3NO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl
  Pathways:Metabolism
  Receptor:FXR
  Boling pt:702.054C
  Melting pt:
  Solubility:DMSO: 100 mg/mL (184.21 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Akwabi-Ameyaw A et al., Bioorg Med Chem Lett, 2008, 18(15), 4339-4343. 2. Maloney PR, et al., J Med Chem, 2000, 43(16), 2971-2974.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting