• Product NameBEZ235 (NVP-BEZ235, Dactolisib)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBEZ235 (NVP-BEZ235, Dactolisib) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
• Target NameATM/ATR inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 915019-65-7
• Calculated MW 469.54
• Formulation C30H23N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C(=O)N(C2=C3C=C(C=CC3=NC=C12)C1=CC2=CC=CC=C2N=C1)C1=CC=C(C=C1)C(C)(C)C#N
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATR; mTOR (p70S6K); p110α; p110γ; p110δ
  Boling pt:701.025C
  Melting pt:
  Solubility:DMF: 18 mg/mL warmed (38.33 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Maira SM, et al. Mol Y Ther, 2008, 7(7), 1851-1863.2. Roper J, et al. PLoS One, 2011, 6(9), e25132.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting