• Product NameU93631
• Brief DescriptionInhibitors
• Purification99.65%
• Biological ActivityGABAA?receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl-?currents with little effect on peak amplitude. Also inhibits 5-HT3A?receptors via a similar mechanism.
• Target NameGABA Receptor antagonist
• CAS No. 152273-12-6
• Calculated MW 299.37
• Formulation C17H21N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1(C2=C(N=CN2C3=CC=CC=C3N1)C(=O)OC(C)(C)C)C
  Pathways:Membrane transporter/Ion channel; Neuroscience
  Receptor:GABA
  Boling pt:
  Melting pt:
  Solubility:DMSO: 34 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dillon,GH et al. Mol Pharmacol. 1993 Oct;44(4):860-5.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting