• Product NameA 740003
• Brief DescriptionInhibitors
• Purification96.53%
• Biological ActivityPotent and selective P2X7?receptor antagonist (IC50?values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100?μM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.
• Target NameP2 Receptor antagonist
• CAS No. 861393-28-4
• Calculated MW 474.55
• Formulation C26H30N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC(C)(C)C(NC(=O)CC1=CC(=C(C=C1)OC)OC)/N=C(\NC#N)/NC2=CC=CC3=C2C=CC=N3
  Pathways:Neuroscience
  Receptor:P2X7 (Human); rat P2X7 receptor
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Honore P, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting