• Product Name3,6'-Disinapoyl sucrose
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activity3,6'-Disinapoyl sucrose has neuroprotective effect and antidepressive activity in rats, at least in part, by increasing expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF).? Treatment with 3,6'-Disinapoyl sucrose (0.6, 6, and 60?μmol/L) increases cell viability dose dependently, inhibits LDH release, and attenuated apoptosis. The mechanisms by which 3,6'-Disinapoyl sucrose protect neuron cells from glutamate-induced excitotoxicity include the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2.
• Target NameBcr-Abl inhibitor; Epigenetic Reader Domain inhibitor
• CAS No. 139891-98-8
• Calculated MW 754.68
• Formulation C34H42O19
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:COC1=CC(=CC(=C1O)OC)/C=C/C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O[C@]3([C@H]([C@@H]([C@H](O3)CO)O)OC(=O)/C=C/C4=CC(=C(C(=C4)OC)O)OC)CO)O)O)O
  Pathways:Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling
  Receptor:Bcl-2; CREB
  Boling pt:
  Melting pt:
  Solubility:Soluble in Pyridine, Methanol, Ethanol
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hu Y, et al. J Mol Neurosci. 2014 Aug;53(4):600-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting