• Product NameIsosilybin
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIsosilybin and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.
• Target NameP450 inhibitor
• CAS No. 72581-71-6
• Calculated MW 482.44
• Formulation C25H22O10
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C=O
  Pathways:Metabolism
  Receptor:CYP3A4
  Boling pt:
  Melting pt:
  Solubility:Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chung PY,et al. Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde. Res Microbiol. 2013 May;164(4):319-26.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting