• Product NameI-CBP112
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityI-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that targets the CBP/p300 bromodomains
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1640282-31-0
• Calculated MW 468.59
• Formulation C27H36N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCC(N1CCOC2=C(OC[C@@H]3CN(C)CCC3)C=C(C4=CC=C(OC)C(OC)=C4)C=C2C1)=O
  Pathways:Chromatin/Epigenetic
  Receptor:CBP/p300( Leukemia cell)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Picaud S,et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75(23):5106-19.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting