The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
[1]Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal."Iverson H.A., Fox D. III, Nadler L.S., Klevit R.E., Nathanson N.M.J. Biol. Chem. 280:24568-24575(2005). [2]The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane." Patowary S., Alvarez-Curto E., Xu T.R., Holz J.D., Oliver J.A., Milligan G., Raicu V.Biochem. J. 452:303-312(2013). [3]Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome."Weber S., Thiele H., Mir S., Toliat M.R., Sozeri B., Reutter H., Draaken M., Ludwig M., Altmuller J., Frommolt P., Stuart H.M., Ranjzad P., Hanley N.A., Jennings R., Newman W.G., Wilcox D.T., Thiel U., Schlingmann K.P. Woolf A.S.Am. J. Hum. Genet. 89:668-674(2011).
