Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
[1]Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs." Zou G., de Leeuw E., Li C., Pazgier M., Li C., Zeng P., Lu W.-Y., Lubkowski J., Lu W.J. Biol. Chem. 282:19653-19665(2007). [2]NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1."Pardi A., Zhang X.-L., Selsted M.E., Skalicky J.J., Yip P.F.Biochemistry 31:11357-11364(1992). [3]NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1." Zhang X.-L., Selsted M.E., Pardi A.Biochemistry 31:11348-11356(1992).
