• Product NameLactadherin Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Lactadherin polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Lactadherin protein
• Target NameLactadherin
• Alternative Names    Breast epithelial antigen BA46 HMFG MFGM Milk fat globule-EGF factor 8 Short name=MFG-E8 SED1 Cleaved into the following 2 chains: Lactadherin short form Medin
• Accession No. Swiss-Prot#: Q08431
• UniprotQ08431
• Gene ID4240;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. Ref.15.Medin is the main constituent of aortic medial amyloid.

[1]Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain.Couto J.R., Taylor M.R., Godwin S.G., Ceriani R.L., Peterson J.A.DNA Cell Biol. 15:281-286(1

• Immunohistochemical analysis of paraffin-embeded human placenta using #42497 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting