Product Detail
Product NameTau(Phospho-Thr181) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
ApplicationsWB IHC
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at threonine 181.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around phosphorylation site of threonine 181 (P-K-T(p)-P-P) derived from Human Tau.
Target NameTau
ConjugateUnconjugated
Other NamesMAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Accession NoSwiss-Prot: P10636
NCBI Protein: NP _001116538.1
Uniprot
P10636
Gene ID
4137;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Puig B, et al.(2005) Acta Neuropathol (Berl). 110(3):261-268.
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If you have published an article using product 11107, please notify us so that we can cite your literature.
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et al,Alzheimer's Disease and Methanol Toxicity (Part 1): Chronic Methanol Feeding Led to Memory Impairments and Tau Hyperphosphorylation in Mice. In J Alzheimers Dis on 2014 by Meifeng Yang, Jing Lu,et al..PMID:24787915
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et al,Role of PrPC in tau protein levels and phosphorylation in Alzheimer's disease evolution. In Mol Neurobiol on 2015 by C Vergara,
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et al,Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. In Cell Signal on 2015 Aug by Mart铆n Roff茅, Fernanda C Lupinacci,et al..PMID:25889895
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et al,Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. In Cell Stem Cell
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et al,Fusobacterium nucleatum infection-induced neurodegeneration and abnormal gut microbiota composition in Alzheimer's disease-like rats
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