Welcome to Sabbiotech!     
Email:info@signalwayantibody.com
Welcome Login Register My Cart(0,$0.00)
Location： Home > Phospho Antibodies > TYK2(Phospho-Tyr1054/1055) Antibody

TYK2(Phospho-Tyr1054/1055) Antibody#11148

Datasheet PDF
Availability： Yes
Total Amount:$
ADD TO CART
Detail Pictures Description Publish(2) Other
Product Detail

Product NameTYK2(Phospho-Tyr1054/1055) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThis antibody detects endogenous levels of Tyk2 only when phosphorylated at Tyr1054 or tyr1055,and dually phosphorylated at two sites.

Immunogen TypePeptide-KLH

Immunogen DescSynthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)

Target NameTYK2

ConjugateUnconjugated

Other Namestyrosine kinase 2; JTK1;

Accession NoSwiss-Prot: P29597
NCBI Protein: NP_003322.3

Uniprot P29597

Gene ID 7297;

Concentration1.0mg/ml

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
WB 1:1000 - 1:2000
Western blot analysis of extracts from HT29 cells untreated(lane 1) or treated with Anisomycin(lane 2) using TYK2(Phospho-Tyr1054) Antibody #11148.

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

If you have published an article using product 11148, please notify us so that we can cite your literature.

et al,6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside Potentiates the Anti-Proliferative Effect of Interferon 伪/尾 by Promoting Activation of the JAK/STAT Signaling by Inhibiting SOCS3 in Hepatocellular Carcinoma Cells.In Toxicol Appl Pharmacol on 2017 Dec 1 by Orawan Wonganan, Yu-Jiao He,et al..PMID: 29031523 , (2017),
PMID: 29031523
et al,Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase , (2017),
PMID: 29371942

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

QUICK NAV

New Products

Cell Signal Transduction

Cancer

Stem Cell

Neuroscience

Help and Support

Contact Us

Terms

Privacy Policy

support

Distributors