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Location： Home > Phospho Antibodies > HDAC5(Phospho-Ser498) Antibody

HDAC5(Phospho-Ser498) Antibody#11193

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Product Detail

Product NameHDAC5(Phospho-Ser498) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ApplicationsWB;IHC;IF

Species ReactivityHu Ms

SpecificityThe antibody detects endogenous level of HDAC5 only when phosphorylated at serine498.

Immunogen TypePeptide-KLH

Immunogen DescThe antiserum was produced against synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498.

Target NameHDAC5

ConjugateUnconjugated

Other NamesHD5

Accession NoSwiss-Prot: Q9UQL6
NCBI Protein: NP_001015053.1

Uniprot Q9UQL6

Gene ID 10014;

Concentration1.0mg/ml

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

WB 1:500-1:2000;
IHC 1:100-1:300; 
IF 1:200-1:1000
 

Western Blot analysis of VEC cells using Phospho-HDAC5 (S498) Polyclonal Antibody diluted at 1:500
Western blot analysis of lysates from Jurkat cells, using HDAC5 (Phospho-Ser498) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using HDAC5 (Phospho-Ser498) Antibody. The picture on the right is blocked with the phospho peptide.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

If you have published an article using product 11193, please notify us so that we can cite your literature.

et al,GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. , (2008),
PMID: 18292392
et al,Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. , (2010),
PMID: 20181743
et al,Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. , (2008),
PMID: 18218981
et al,Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. , (2010),
PMID: 20042720
et al,DopamIne receptor antagonists as potential therapeutic agents for ADPKD. In PLoS One on 2019 May 6 by Paul P, Ramachandran S et al.. PMID:31059522 , (2019),
PMID: 31059522
et al,Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.In Blood on 2010 Apr 8 by Weiye Wang, Chang Hoon Ha,et al..PMID:20042720 , (2010),
PMID: 20042720
et al,Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. In Development on 2010 Apr by Sheng Xia, Xiaogang Li, et al..PMID: 20181743 , (2010),
PMID: 20181743

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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