Product Detail
Product NameSTAT2(phospho-Tyr690) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from Human Stat2
Target NameSTAT2
ConjugateUnconjugated
Other NamesP113; ISGF-3; STAT113; MGC59816;
Accession NoSwiss-Prot: P52630
NCBI Protein: NP_005410.1
Uniprot
P52630
Gene ID
6773;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 113kd
Western blotting: 1:1000
Western blot analysis of extracts from Hela cells untreated or treated with IFN-a using Stat2(phospho-Tyr690) Antibody #11536.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has
been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992)
Yan R,et al. Nucleic Acids Res. 23:459-463(1995)
Fu X.Y.Cell 70:323-335(1992)
Sugiyama T,et al.FEBS Lett. 381:191-194(1996)
If you have published an article using product 11536, please notify us so that we can cite your literature.
et al,6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside Potentiates the Anti-Proliferative Effect of Interferon 伪/尾 by Promoting Activation of the JAK/STAT Signaling by Inhibiting SOCS3 in Hepatocellular Carcinoma Cells.In Toxicol Appl Pharmacol on 2017 Dec 1 by Orawan Wonganan, Yu-Jiao He,et al..PMID: 29031523
, (2017),
PMID:
29031523
et al,Expression of interferon effector gene SART1 correlates with interferon treatment response against hepatitis B infection. In Mediators Inflamm on 2016 by Yong Li, Chuanlong Zhu et al..PMID: 28077916
, (2016),
PMID:
28077916
et al,CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis.
, (2025),
PMID:
40122504
Yes
