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DRP1 (Phospho-Ser637) Antibody#11842

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Product NameDRP1 (Phospho-Ser637) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ApplicationsWB,IHC,IF,ELISA

Species ReactivityHu Rt Ms

SpecificityThe antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Immunogen TypePeptide-KLH

Immunogen DescSynthesized phospho-peptide around the phosphorylation site of human DRP1 (phospho Ser637)

Target NameDRP1

ConjugateUnconjugated

Other NamesDLP1; DNM1L; DRP1; DVLP; Dymple

Accession NoSwiss-Prot#: O00429;
NCBI Gene#: 10059;
NCBI Protein#: NP_036192.2.

Uniprot O00429

Gene ID 10059;

Sdspage MW82kd

Concentration1mg/ml

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20˚C/1 year

Application Details

WB 1:500-1:2000
IHC: 1:100-300
IF 1:100-300
ELISA 1:20000

Western Blot analysis of JK cells using Phospho-DRP1 (S637) Polyclonal Antibody
Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
Immunofluorescence analysis of A549. 1,primary Antibody(red) was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - Alexa Fluor 594 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min.

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.

Shin H.-W., J. Biochem. 122:525-530(1997).
Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).
Imoto M., J. Cell Sci. 111:1341-1349(1998).

If you have published an article using product 11842, please notify us so that we can cite your literature.

et al,AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis. In Sci Total Environ on 2024 Sep 15 by Liting Cheng, Mingxiang Zhu,et al..PMID:39474068 , (2024),
PMID: 39474068
et al,Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms. , (2025),
PMID: 39736347

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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