Welcome to Sabbiotech!     
Email:info@signalwayantibody.com
Welcome Login Register My Cart(0,$0.00)
Location： Home > Phospho Antibodies > HER4 (Phospho-Tyr1284) Antibody

HER4 (Phospho-Tyr1284) Antibody#12046

Datasheet PDF
Availability： Yes
Total Amount:$
ADD TO CART
Detail Pictures Description Publish(0) Other
Product Detail

Product NameHER4 (Phospho-Tyr1284) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ApplicationsWB;IHC;IF

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of p38 HER4 only when phosphorylated at Tyrosine 1284.

Immunogen TypePeptide-KLH

Immunogen DescThe antiserum was produced against synthesized peptide derived from human HER4 around the phosphorylation site of Tyr1284.

Target NameHER4

ConjugateUnconjugated

Other NamesHER4, p180erbB4

Accession NoSwiss-Prot#: Q15303;
NCBI Gene#: 2066;
NCBI Protein#: NP_001036064.1

Uniprot Q15303

Gene ID 2066;

Sdspage MW180kd

Concentration1.0mg/ml

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20˚C/1 year

Application Details

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000.

Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 30'. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells treated with EGF 200nM 5'. The picture on the right is blocked with the phospho peptide.

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],

If you have published an article using product 12046, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

QUICK NAV

New Products

Cell Signal Transduction

Cancer

Stem Cell

Neuroscience

Help and Support

Contact Us

Terms

Privacy Policy

support

Distributors