Product Detail
Product NamePERK (Phospho-Thr 982) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity purification using immunogen.
ApplicationsWB
Species ReactivityHu Ms Rt
Specificityp-PERK (Phospho-Thr 982) Antibody detects endogenous levels of total p-PERK at Thr 982.
Immunogen TypePeptide
Immunogen DescA synthesized peptide derived from human PERK around the phosphorylation site of Thr982.
Target Namep-PERK (Phospho-Thr 982)
ConjugateUnconjugated
Other NamesEIF2AK3, HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PERK, PKR-like ER kinase, WRS
Accession NoSwiss-Prot#: Q9NZJ5
NCBI Gene ID: 9451
Uniprot
Q9NZJ5
Gene ID
9451;
Calculated MW125 kDa
Concentration1.0mg/mL
FormulationRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Target Specieshuman
Application Details
Western blotting: 1:1000-3000
If you have published an article using product 12814, please notify us so that we can cite your literature.
et al,Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2伪-ATF4 pathway.
, (2017--31),
PMID:
28578014
et al,Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.In Cell Death Dis. On 2018 Oct 17 by Kim HJ, Joe Y et al..PMID: 30333475
, (2018),
PMID:
30333475
et al,Deficiency of fibroblast growth factor 21 aggravates obesity-Induced atrophic responses In skeletal muscle. In J Inflamm (Lond) on 2019 Jul 4 by Kim CS, Joe Y, et al..PMID:31312114
, (2019),
PMID:
31312114
et al,High glucose and bupivacaIne?Induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK?ATF4?CHOP and IRE1?TRAF2 signalIng pathways. In Mol Med Rep on 2019 Sep by Liu Y, Sun L, et al..PMID:31524237
, (2019),
PMID:
31524237
et al,Carbon Monoxide Protects Against Hepatic Steatosis in Mice by Inducing sestrin-2 via the PERK-eIF2伪-ATF4 Pathway.In Free Radic Biol Med on 2017 Sep by Hyo Jeong Kim, Yeonsoo Joe,et al..PMID: 28578014
, (2017),
PMID:
28578014
et al,Magnesium Isoglycyrrhizinate Promotes the Activated Hepatic Stellate Cells Apoptosis via Endoplasmic Reticulum Stress and Ameliorates Fibrogenesis in Vitro and in Vivo.In Biofactors on 2017 Nov by Mianli Bian , Xingran Chen,et al..PMID: 29048780
, (2017),
PMID:
29048780
et al,Quercetin Stimulates Mitochondrial Apoptosis Dependent on Activation of Endoplasmic Reticulum Stress in Hepatic Stellate Cells .In Pharm Biol. On 2016 Dec by Liwei He , Xianbang Hou et al..PMID:27572285
, (2016),
PMID:
27572285
More
et al,Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway. In Brain Res Bull on 2020 Sep by Yi Liu, Di Wen, et al..PMID:32544512
, (2020),
PMID: 32544512
et al,Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury. In Aging (Albany NY) on 2020 Aug 28 by Jing-Yao Song, Bin Fan,et al..PMID: 32858529
, (2020),
PMID: 32858529
et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681
, (2021),
PMID: 33604681
et al,纬-Glutamylcysteine Alleviates Ischemic Stroke-Induced Neuronal Apoptosis by Inhibiting ROS-Mediated Endoplasmic Reticulum Stress. In Oxid Med Cell Longev on 2021 Nov 16 by Hui-Qin Li, Sheng-Nan Xia, et al..PMID:34824669
, (2021),
PMID: 34824669
et al,PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEBinduced Autophagy-Lysosomal Pathway
, (2021),
PMID:
et al,Malondialdehyde-Acetaldehyde Extracellular Matrix Protein Adducts Attenuate Unfolded Protein Response During Alcohol and Smoking–Induced Pancreatitis. In Gastroenterology on 2022 Oct by Rakesh Bhatia, Christopher M Thompson, et al..PMID: 35788346
, (2022),
PMID: 35788346
et al,PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway. In Aging (Albany NY) on 2022 Feb 15 by Mihyang Do, Jeongmin Park, et al..PMID:35166693
, (2022),
PMID: 35166693
et al,The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. In Int J Mol Sci on 2022 Jan 25 by Meiyu Cheng, Huimei Yu, et al..PMID: 35163244
, (2022),
PMID: 35163244
et al,Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathwayIn J Nutr BiochemOn2023 AugbyJeongmin Park , Jeong Heon Gong et al..PMID:36958418
, (2023),
PMID: 36958418
et al,Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells
, (2024),
PMID:
et al,The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity
, (2025),
PMID:
et al,CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.
, (2025),
PMID: 39378914
Yes
