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Location： Home > Phospho Antibodies > LATS2 (Phospho-Ser872) Antibody

LATS2 (Phospho-Ser872) Antibody#12875

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Product Detail

Product NameLATS2 (Phospho-Ser872) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityPhospho-LATS2 (S872) Antibody detects endogenous levels of LATS2 only when phosphorylated at S872

Immunogen TypePeptide-KLH

Immunogen DescA synthesized peptide derived from human LATS2 (Phospho-Ser872)

ConjugateUnconjugated

Other NamesFLJ13161 antibody Kinase phosphorylated during mitosis protein antibody KPM antibody Large tumor suppressor homolog 2 antibody Large tumor suppressor homolog 2 Drosophila antibody Large tumor suppressor kinase 2 antibody LATS large tumor suppressor Drosophila homolog 2 antibody LATS large tumor suppressor homolog 2 antibody Lats2 antibody LATS2_HUMAN antibody Serine threonine kinase kpm antibody Serine threonine protein kinase kpm antibody Serine threonine-protein kinase kpm antibody Serine threonine-protein kinase LATS2 antibody Warts like kinase antibody Warts-like kinase antibody

Accession NoSwiss-Prot#:Q9NRM7
NCBI Gene ID26524

Uniprot Q9NRM7

Gene ID 26524;

Calculated MW150

Concentration1.0mg mL

FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.

StorageStore at -20˚C

Application Details

WB dilution:1:1000

LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1,S transition by down-regulating cyclin E,CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)?

If you have published an article using product 12875, please notify us so that we can cite your literature.

et al,Identification of the kInase STK25 as an upstream activator of LATS signalIng. In Nat Commun on 2019 Apr 4 by Lim S, Hermance N, et al..PMID:30948712 , (2019),
PMID: 30948712
et al,The CalcR-PKA-Yap1 Axis Is Critical for MaIntaInIng Quiescence In Muscle Stem Cells. In Cell Rep on 2019 Nov 19 by Zhang L, Noguchi YT, et al..PMID:31747590 , (2019),
PMID: 31747590

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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