Product Detail
Product NameTNK1 (phospho-Tyr277) rabbit pAb
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
ApplicationsWB
Species ReactivityHuman
SpecificityThis antibody detects endogenous levels of Human TNK1 (phospho-Tyr277)
Immunogen DescSynthesized phosho peptide around human TNK1 (Tyr277)
ConjugateUnconjugated
Other NamesNon-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
Accession NoSwiss Prot:Q13470
GeneID:8711
Uniprot
Q13470
Gene ID
8711
Sdspage MW75
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
WB 1:1000-2000
tyrosine kinase non receptor 1(TNK1) Homo sapiens The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
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