Product Detail
Product NameRb (phospho Ser612) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsIHC-p,IF(paraffin section),ELISA
Species ReactivityHuman
SpecificityPhospho-Rb (S612) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S612.
Immunogen DescSynthesized phospho-peptide around the phosphorylation site of human Rb (phospho Ser612)
ConjugateUnconjugated
Other NamesRB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Accession NoSwiss Prot:P06400
GeneID:5925
Uniprot
P06400
Gene ID
5925
Calculated MW106kd
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
Immunohistochemistry: 1/100 - 1/300.
ELISA: 1/5000. Not yet tested in other applications.
RB transcriptional corepressor 1(RB1) Homo sapiens The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
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Yes
