Product Detail
Product Namep53 (phospho Ser378) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB,ELISA
Species ReactivityHuman,Mouse,Rat
SpecificityPhospho-p53 (S378) Polyclonal Antibody detects endogenous levels of p53 protein only when phosphorylated at S378.
Immunogen DescThe antiserum was produced against synthesized peptide derived from human p53 around the phosphorylation site of Ser378. AA range:344-393
ConjugateUnconjugated
Other NamesTP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
Accession NoSwiss Prot:P04637
GeneID:7157
Uniprot
P04637
Gene ID
7157
Sdspage MW53
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
Western Blot: 1/500 - 1/2000.
ELISA: 1/20000. Not yet tested in other applications.
tumor protein p53(TP53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013],
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