Product Detail
Product NameHuntingtin (phospho Ser421) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsIHC;IF;ELISA
Species ReactivityHuman,Mouse,Rat
SpecificityPhospho-Huntingtin (S421) Polyclonal Antibody detects endogenous levels of Huntingtin protein only when phosphorylated at S421.
Immunogen DescThe antiserum was produced against synthesized peptide derived from human Huntingtin around the phosphorylation site of Ser421. AA range:387-436
ConjugateUnconjugated
Other NamesHTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein
Accession NoSwiss Prot:P42858
GeneID:3064
Uniprot
P42858
Gene ID
3064
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
IHC 1:100-1:300;
ELISA 1:5000; IF 1:50-200
huntingtin(HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel
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