Product Detail
Product NameGIT2 (phospho-Tyr592) rabbit pAb
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
ApplicationsWB
Species ReactivityHuman
SpecificityThis antibody detects endogenous levels of Human GIT2 (phospho-Tyr592)
Immunogen DescSynthesized phosho peptide around human GIT2 (Tyr592)
ConjugateUnconjugated
Other NamesARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Accession NoSwiss Prot:Q14161
GeneID:9815
Uniprot
Q14161
Gene ID
9815
Sdspage MW84
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
WB 1:1000-2000
GIT ArfGAP 2(GIT2) Homo sapiens This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
If you have published an article using product 13838, please notify us so that we can cite your literature.
Yes
