Product Detail
Product NameFLT3 (phospho-Tyr589/591) rabbit pAb
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
ApplicationsWB
Species ReactivityHuman,Mouse
SpecificityThis antibody detects endogenous levels of Human Mouse FLT3 (phospho-Tyr589 or 591)
Immunogen DescSynthesized phosho peptide around human FLT3 (Tyr589 and 591)
ConjugateUnconjugated
Other NamesReceptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Accession NoSwiss Prot:P36888
GeneID:2322
Uniprot
P36888
Gene ID
2322
Sdspage MW117
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
WB 1:1000-2000
fms related tyrosine kinase 3(FLT3) Homo sapiens This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],
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Yes
