Product Detail
Product NameALK (Phospho-Tyr1586) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
ApplicationsWB;IHC;IF
Species ReactivityHuman:Y1586, Mouse:Y1592
SpecificityThis antibody detects endogenous phospho levels of ALK (Phospho-Tyr1586) at Human:Y1586, Mouse:Y1592
Immunogen DescSynthesized peptide derived from human ALK (Phospho-Tyr1586)
ConjugateUnconjugated
Other NamesALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Accession NoSwiss Prot:Q9UM73
GeneID:238
Uniprot
Q9UM73
Gene ID
238
Sdspage MW176
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
IHC 1:50-200; WB 1:500-2000; IF 1:50-200
anaplastic lymphoma receptor tyrosine kinase(ALK) Homo sapiens This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome
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The lead time is 1 month
