Product Detail
Product NameSTAT3(Ab-705) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IHC IF
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total STAT3 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.703~707(A-P-Y-L-K) derived from Human STAT3.
Target NameSTAT3
ConjugateUnconjugated
Other NamesAPRF; Acute-phase response factor; HIES
Accession NoSwiss-Prot: P40763
NCBI Protein: NP_003141.2
Uniprot
P40763
Gene ID
6774;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 88kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: IF:1:100~1:200
Western blot analysis of extracts from Hela cells using STAT3(Ab-705) Antibody #21045(lane 1
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT3(Ab-705) antibody(#21045).
Immunofluorescence staining of methanol-fixed HeLa cells using STAT3(Ab-705) antibody
(#21045, Red).
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120.
Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804.
Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115.
Garcia R, et al. (1998) J Biomed Sci. 5: 79-85.
Bromberg J F, et al. (1999) Cell. 98: 295-303.
If you have published an article using product 21045, please notify us so that we can cite your literature.
et al,A novel IFIH1 mutation in the pincer domain underlies the clinical features of both Aicardi-Gouti res and Singleton-Merten syndromes in a single patient.In Br J Dermatol. On 2018 Feb by Takeichi T, Katayama C et al..PMID:29270977
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et al,Effect of STAT3 decoy oligodeoxynucleotides mediated by ultrasound-targeted microbubbles combIned with ultrasound on the growth of squamous cell carcInoma of the esophagus. In Oncol Lett on 2019 Feb by Zhang Y, Zhang M, et al..PMID:30675281
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et al,A thiazole-derived oridonIn analogue exhibits antitumor activity by directly and allosterically InhibitIng STAT3. In J Biol Chem on 2019 Nov 15;by Shen X, Zhao L,et al..PMID:31594861
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et al,Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3
survival pathway.In Braz J Med Biol Res on 2012 Oct by Luan HF, Zhao ZB,et al..PMID:22948409
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et al,Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling.In Hepatology on 2011 Sep 2 by Yu HC, Qin HY,et al..PMID:21633967
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et al,Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to That Seen in the Psoriatic Condition.In J Invest Dermatol on 2010 Dec by Takuya Takeichi, Kazumitsu Sugiura, et al..PMID:20631726
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et al,Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K鈥揂kt signaling pathways. In Regul Pept on 2013 Feb 10 by Libing Ma, Jinxiu Li, et al..PMID: 23327998
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et al,A Guanidine-Rich Regulatory Oligodeoxynucleotide Improves type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation. In EMBO Mol Med on 2012 Oct by Xiang Cheng, Jing Wang, et al..PMID:23027613
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et al,Girdin/GIV is upregulated by cyclic tension, propagates mechanical signal transduction, and is required for the cellular proliferation and migration of MG-63 cells.In Biochem Biophys Res Commun.On 2015 Aug 21 by Hu JT, Li Y et al..PMID:26163263
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et al,Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling.In Cell Signal on 2014 Sep by Peng Yang, Zongwei Li et al..PMID:24686087
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et al,Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. In Cell Signal on 2015 Jul by Peng Yang, Zongwei Li, et al..PMID:25778902
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et al,Regulatory Effect of Baicalin on the Imbalance of Th17/Treg Responses in Mice With Allergic Asthma. In J Ethnopharmacol on 2017 Aug 17 by Lu Xu , Jinxia Li, et al..PMID: 28709893
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et al,Magnolol Attenuates Right Ventricular Hypertrophy and Fibrosis in Hypoxia-Induced Pulmonary Arterial Hypertensive Rats Through Inhibition of the JAK2/STAT3 Signaling Pathway. In Front Pharmacol on 2021 Oct 26 by Minyi Fu, Fangmei Luo,et al..PMID:34764873
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