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STAT3(Ab-727) Antibody#21046

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Product Detail

Product NameSTAT3(Ab-727) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB IHC

Species ReactivityHu

SpecificityThe antibody detects endogenous level of total STAT3 protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa. 725~729 (P-M-S-P-R) derived from Human STAT3.

Target NameSTAT3

ConjugateUnconjugated

Other NamesAcute-phase response factor

Accession NoSwiss-Prot: P40763
NCBI Protein: NP_003141.2

Uniprot P40763

Gene ID 6774;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 88kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT3(Ab-727) Antibody #21046(left) or the same antibody preincubated with blocking peptide(right).
Western Blot analysis of Hela /293 cells using STAT3 Polyclonal Antibody
Western blot analysis of extracts from Hela cells using STAT3(Ab-727) Antibody #21046.

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Heim M H, (1999) J Recept Signal Transduct Res. 19: 75-120.
Takeda K, et al. (1997) Proc Natl Acad Sci USA. 94: 3801-3804.
Catlett-Falcone R, et al. (1999) Immunity. 10: 105-115.
Garcia R, et al. (1998) J Biomed Sci. 5: 79-85.
Bromberg J F, et al. (1999) Cell. 98: 295-303.

If you have published an article using product 21046, please notify us so that we can cite your literature.

et al,PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival.In Front Oncol on 2020 Apr 15 by Ma H, Wang H, et al..PMID: 32351883 , (2020),
PMID: 32351883
et al,Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. In PLoS One on 2010 Oct 7 by Emilio Garc铆a-Prieto, Adri谩n Gonz谩lez-L贸pez, et al..PMID: 20949050 , (2010),
PMID: 20949050
et al,Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus. In Virol J on 2012 Aug 21 by Jun Hou, Lianghai Wang, et al..PMID: 22909062 , (2012),
PMID: 22909062
et al,A Guanidine-Rich Regulatory Oligodeoxynucleotide Improves type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation. In EMBO Mol Med on 2012 Oct by Xiang Cheng, Jing Wang, et al..PMID:23027613 , (2012),
PMID: 23027613
et al,Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. In J Agric Food Chem on 2016 Aug 17 by Min Guo, Guo-Bin Ding,et al..PMID: 27465400 , (2016),
PMID: 27465400

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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