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Location： Home > Polyclonal Antibodies > BCL-XL(Ab-62) Antibody

BCL-XL(Ab-62) Antibody#21061

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Product Detail

Product NameBCL-XL(Ab-62) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total BCL-XL protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .

Target NameBCL-XL

ConjugateUnconjugated

Other NamesApoptosis regulator Bcl-X

Accession NoSwiss-Prot: Q07817
NCBI Protein: NP_612815.1

Uniprot Q07817

Gene ID 598;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 30kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from 293 and Hela cells using BCL-XL(Ab-62) antibody #21061.
Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Basu A, et.al.( 2003) Mar 13; 538(1-3): 41-7
Cheng E.H.-Y. et.al. (1996) Nature 379:554-556.
Sattler M. et.al. (1997), Science 275:983-986.
Muchmore S.W.et.al (1996).Nature 381:335-341
Yu J., Zhang L. Mol. (2001)Cell 7:673-682

If you have published an article using product 21061, please notify us so that we can cite your literature.

et al,Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway.In Int J Mol Med. On 2018 Apr by Yuan J, Zhao X et al..PMID: 29344647 , (2018),
PMID: 29344647
et al,Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. In Int J Mol Med on 2019 Jan by DIng Y, Jiang Z, et al..PMID:30431108 , (2019),
PMID: 30431108
et al,Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. In Int J Mol Med on 2019 Jan by Yu DIng, Zhaochang Jiang, et al..PMID: 30431108 , (2019),
PMID: 30431108
et al,Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. In Int J Mol Med on 2019 Jan by DIng Y, Jiang Z, et al..PMID:30431108 , (2019),
PMID: 30431108
et al,PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival.In Front Oncol on 2020 Apr 15 by Ma H, Wang H, et al..PMID: 32351883 , (2020),
PMID: 32351883
et al,Anticancer effects of sodium butyrate on hepatocellular carcinoma cells in vitro. In Int J Mol Med on 2013 Apr by Hong-Gang Wang, Xiao-Dan Huang, et al..PMID: 23440283 , (2013),
PMID: 23440283
et al,Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.In Am J Transl Res. On 2016 Sep 15 by SH Li, WC Dong et al..PMID:27725861 , (2016),
PMID: 27725861
More
et al,miR-137 and miR-197 induce apoptosis and suppress tumorigenicity by targeting MCL-1 in multiple myeloma.In Clin Cancer Res on 2015 May 15 by Yijun Yang , Fei Li et al..PMID:25724519 , (2015),
PMID: 25724519
et al,The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell linesInTransl OncolOn 2023 JanbyJeongjae Lee, Bhumsuk Keam et al..PMID:36436443 , (2023),
PMID: 36436443

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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