Product Detail
Product NameVEGFR2(Ab-951) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IHC IF
Species ReactivityHu
SpecificityThe antibody detects endogenous level of total VEGFR2 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.949~953 (K-D-Y-V-G) derived from Human VEGFR2.
Target NameVEGFR2
ConjugateUnconjugated
Other NamesFLK1; KDR; VGFR2; VGR2; kinase insert domain receptor
Accession NoSwiss-Prot: P35968
NCBI Protein: NP_002244.1
Uniprot
P35968
Gene ID
3791;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 230kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from SKOV3 cells using VEGFR2(Ab-951) Antibody #21079 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using VEGFR2(Ab-951) Antibody #21079(left) or the same antibody preincubated with blocking peptide(right).
Immunofluorescence staining of methanol-fixed MCF cells using VEGFR2(Ab-951) Antibody #21079.
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Zeng H, et al. (2001) J Biol Chem. 276(35): 32714-32719.
Dougher M, et al. (1999) Oncogene. 18(8): 1619-1627.
If you have published an article using product 21079, please notify us so that we can cite your literature.
et al,Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.
, (2011),
PMID:
21943225
et al,Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain.
, (2010),
PMID:
20637274
et al,Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.
, (2012),
PMID:
23082896
et al,Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system
in the brain.In J Ethnopharmacol on 2010 Sep 15 by Qi Zhao, Takako Yokozawa,et al..PMID:20637274
, (2010),
PMID:
20637274
et al,Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic
factors and neuroplasticity systems in the brain. In Chin Med on 2011 Sep 23 by Qi Zhao, Takako Yokozawa, et al..PMID: 21943225
, (2011),
PMID:
21943225
et al,Chotosan Ameliorates Cognitive and Emotional Deficits in an Animal Model of Type 2 Diabetes: Possible Involvement of Cholinergic and VEGF/PDGF Mechanisms in the Brain. In BMC Complement Altern Med 2012 Oct 20 by Qi Zhao, Yimin Niu, et al..PMID:23082896
, (2012),
PMID:
23082896
et al,Artesunate Inhibits Proliferation and Invasion of Mouse Hemangioendothelioma Cells in vitro and of Tumor Growth in vivo.In Oncol Lett on 2017 Nov by Ning Wang , Hongxia Chen,et al..PMID: 29113263
, (2017),
PMID:
29113263
More
et al,Maternal protein restriction alters VEGF signaling and decreases pulmonary alveolar in fetal rats.In Int J Clin Exp Pathol on 2014 May 15 by Xiaomei Liu , Yan Lin et al ..PMID: 25031729
, (2014),
PMID: 25031729
et al,CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development.In Cell Res on 2015 Mar by Wei Chen, Yan Liu et al..PMID:25656845
, (2015),
PMID: 25656845
et al,Possible involvement of VEGF signaling system in rescuing effect of endogenous acetylcholine on NMDA-induced long-lasting hippocampal cell damage in organotypic hippocampal slice cultures. In Neurochem Int on 2014 Sep by Chikako Inada, Yimin Niu,et al..PMID:24911952
, (2014),
PMID: 24911952
Yes
