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Tau(Ab-396) Antibody#21093

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Product Detail

Product NameTau(Ab-396) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total Tau protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa. 394~398 (Y-K-S-P-V) derived from Human Tau.

Target NameTau

ConjugateUnconjugated

Other NamesNeurofibrillary tangle protein; Paired helical filament-tau;

Accession NoSwiss-Prot: P10636
NCBI Protein: NP _001116538.1

Uniprot P10636

Gene ID 4137;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from mouse brain tissue using Tau(Ab-396) Antibody #21093.
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.
DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.
Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.

If you have published an article using product 21093, please notify us so that we can cite your literature.

et al,Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.In Eur J Anaesthesiol on 2010 Sep by Tan W, Cao X, et al..PMID:20485178 , (2010),
PMID: 20485178
et al,Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats.In Clin Exp Pharmacol Physiol on 2010 Oct by Tan WF, Cao XZ,et al..PMID:20659131 , (2010),
PMID: 20659131
et al,Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta Menthoides as a Traditional "Hot" Herb Reverses the Impairment.In Iran J Pharm Res on Winter 2014 by Mohammad Mahdi ,Ahmadian-Attar et al..PMID:24711845 , (2014),
PMID: 24711845
et al,Impairment of rat spatial learning and memory in a new model of cold water-induced chronic hypothermia: implication for Alzheimer's disease.In Neurotox Res on 2015 Aug by Mohammad Mahdi Ahmadian-Attari, Leila Dargahi et al..PMID:25782579 , (2015),
PMID: 25782579
et al,Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid 尾42 in mice.In Brain Res on 2015 Aug 27 by Yi-Pei Li, Guo-Jun Yang et al..PMID:26049128 , (2015),
PMID: 26049128
et al,Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. In Transl Psychiatry on 2020 Jul 13 by Jun Wang, Bin-Lu Sun,et al..PMID:32661266 , (2020),
PMID: 32661266
et al,Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficitsInAging (Albany NY)On2023 Dec 12byLing Lei?1?2,?Yong Luo et al..PMID:?38095632 , (2023),
PMID: 38095632

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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