Product Detail
Product NameTau(Ab-235) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu Ms
SpecificityThe antibody detects endogenous level of total Tau protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa. 233~237 (P-K-S-P-S) derived from Human Tau.
Target NameTau
ConjugateUnconjugated
Other NamesNeurofibrillary tangle protein; Paired helical filament-tau;
Accession NoSwiss-Prot: P10636
NCBI Protein: NP _001116538.1
Uniprot
P10636
Gene ID
4137;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from mouse brain tissue using Tau(Ab-235) Antibody #21095.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.
Liu F, et al. (2002) FEBS Lett. 530(1-3): 209-214.
Sengupta A, et al. (1998) Arch Biochem Biophys. 357(2): 299-309.
If you have published an article using product 21095, please notify us so that we can cite your literature.
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