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Tau(Ab-231) Antibody#21099

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Product Detail

Product NameTau(Ab-231) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total Tau protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa. 229~233 (V-R-T-P-P) derived from Human Tau.

Target NameTau

ConjugateUnconjugated

Other NamesNeurofibrillary tangle protein; Paired helical filament-tau;

Accession NoSwiss-Prot: P10636
NCBI Protein: NP _001116538.1

Uniprot P10636

Gene ID 4137;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from mouse brain tissue using Tau(Ab-231) Antibody #21099.
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Yen S.H.et.al. (1997) Neurochem. 69:1709-1719.
Beausoleil S.A.et.al. (2004) Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135.
Wintjens R.et.al. (2001) Biol. Chem. 276:25150-25156.
Babu J.R.et.al.(2005) Neurochem. 94:192-203.
Goedert M., Spillantini M.G. (2000) Biochim. Biophys. Acta 1502:110-121.

If you have published an article using product 21099, please notify us so that we can cite your literature.

et al,Oleocanthal enhances amyloid-尾 clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model. In ACS Chem Neurosci on 2015 Nov 18 by Hisham Qosa, Yazan S Batarseh,et al..PMID:26348065 , (2015),
PMID: 26348065
et al,Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-β and Prevents Alzheimer's Disease-Type Pathology and Cognitive Deficits , (2023),
PMID: 37316674

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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