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TYK2(Ab-1054) Antibody#21118

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Product Detail

Product NameTYK2(Ab-1054) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsIHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total TYK2 protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.

Target NameTYK2

ConjugateUnconjugated

Other Namestyrosine kinase 2; JTK1;

Accession NoSwiss-Prot: P29597
NCBI Protein: NP_003322.3

Uniprot P29597

Gene ID 7297;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 140kd
Immunohistochemistry: 1:50~1:100

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TYK2(Ab-1054) Antibody #21118(left) or the same antibody preincubated with blocking peptide(right).

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

If you have published an article using product 21118, please notify us so that we can cite your literature.

et al,6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside Potentiates the Anti-Proliferative Effect of Interferon 伪/尾 by Promoting Activation of the JAK/STAT Signaling by Inhibiting SOCS3 in Hepatocellular Carcinoma Cells.In Toxicol Appl Pharmacol on 2017 Dec 1 by Orawan Wonganan, Yu-Jiao He,et al..PMID: 29031523 , (2017),
PMID: 29031523

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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