Product Detail
Product NameHistone H3.1(Ab-10) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IF
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Histone H3.1 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.8~12 (R-K-S-T-G) derived from Human Histone H3.1.
Target NameHistone H3.1
ConjugateUnconjugated
Other NamesH3/a; H3/c; H3/d; H3/f; H3/h
Accession NoSwiss-Prot: P68431
NCBI Protein: NP_003521.2
Uniprot
P68431
Gene ID
8350;8351;8352;8353;8354;8355;8356;8357;8358;8968;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 17kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79.
Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41.
Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5.
Cheung, P. et al. (2000) Cell 103, 263-71.
If you have published an article using product 21137, please notify us so that we can cite your literature.
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et al,Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-娄脢B signaling pathway
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PMID:
21376787
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PMID:
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et al,Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway.
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PMID:
21608020
et al,Cancer Cells Phosphorylation of Both Proteins in Breast on Interacting with c-Fos and Hepatitis B X-interacting Protein Depends The Nuclear Import of Oncoprotein.
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et al,Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice.In Biol Open. On 2018 Nov 12 et al..PMID: 30420384
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PMID:
30420384
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et al,DNA?PKcs PARylation regulates DNA?PK kInase activity In the DNA damage response. In Mol Med Rep on 2019 Oct by Han Y, JIn F,et al..PMID:31485633
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PMID: 31485633
et al,Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development.In J Nutr Biochem. On 2018 Jul by Tian Y, Xu Q et al..PMID:29694938
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PMID:
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et al,Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-魏B signaling pathway.In Fitoterapia on 2011 Jun
by Yu C, Shan T,et al..PMID:21376787
, (2011),
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et al,Magnesium deficiency promotes secretion of high-mobility group box 1 protein from lipopolysaccharide-activated macrophages in vitro.In J Surg Res on 2013 Apr by Liu Z, Chang Y,et al..PMID:22608546
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PMID: 22608546
et al,Aberrant Hypermethylation and Reduced Expression of disabled-2 Promote the Development of Lung Cancers.In Int J Oncol on 2013 Nov by Xue-Mei Xie, Zi-Yin Zhang,et al..PMID:24002585
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et al,Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPAR纬/NF-魏B
pathway.In Respir Res on 2012 Dec 2 by Liao Z, Dong J,et al..PMID:23199346
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et al,Quercetin Attenuates Airway Inflammation and Mucus Production Induced by Cigarette Smoke in Rats.In Int Immunopharmacol on 2012 May by Ting Yang, Feng Luo,et al..PMID:22465384
, (2012),
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et al,Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway.In J Cell Biochem on 2011 Oct by Xiangyang Yao, Fenfen Zhu, et al..PMID:21608020
, (2011),
PMID: 21608020
et al,Protective effects of Salvianolic acid B on Schwann cells apoptosis induced by high glucose. In Neurochem Res on 2012 May by Lian-Qing Sun, Jue Zhao, et al..PMID:
22252725
, (2012),
PMID: 22252725
et al,CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. In J Biol Chem on 2008 Nov 21 by Guo-Dong Li, Xi Zhang, et al..PMID:18815128
, (2008),
PMID: 18815128
et al,Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. In Planta Med on 2012 Nov by Xiangyang Yao, Guilan Li, et al..PMID: 22961117
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PMID: 22961117
et al,Sirt1 Attenuates Camptothecin-Induced Apoptosis Through caspase-3 Pathway in Porcine Preadipocytes. In Exp Cell Res on 2013 Mar 10 by Wei-jun Pang, Yan Xiong, et al..PMID: 23313858
, (2013),
PMID: 23313858
et al,FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short . In PLoS One on 2012 by Song Chen, Hedeel Guy Evans, et al..PMID: 22427918
, (2012),
PMID: 22427918
et al,Decreased expression of profilin 2 in oral squamous cell carcinoma and its clinicopathological implications. In Oncol Rep on 2011 Oct by C Y Ma, C P Zhang, et al..PMID:21725608
, (2011),
PMID: 21725608
et al,Effects of Yishen Pinggan Recipe on Renal Protection and NF-魏B Signaling Pathway in Spontaneously Hypertensive Rats.In Evid Based Complement Alternat Med on 2016 by Guodong Luo , Xiying Zhu et al..PMID:27069492
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PMID: 27069492
et al,Chinese medicine Bu Xu Hua Yu recipe for the regulation of Treg/Th17 ratio imbalance in autoimmune hepatitis.In Evid Based Complement Alternat Med on 2015 by Lei Wang, Huihui Du et al..PMID: 25977698
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PMID: 25977698
et al,NF1, Sp1 and HSF1 are synergistically involved in sulfide-induced sqr activation in echiuran worm Urechis unicinctus.In Aquat Toxicol on 2016 Jun by Xiaolong Liu , Zhenkui Qin et al..PMID: 27070384
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PMID: 27070384
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