Product Detail
Product NameDab1(Ab-232) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsIHC
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Dab1 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1.
Target NameDab1
ConjugateUnconjugated
Other NamesDisabled homolog 1
Accession NoSwiss-Prot: O75553
NCBI Protein: NP_066566.3
Uniprot
O75553
Gene ID
1600;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 80kd
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Dab1(Ab-232) Antibody #21251(left) or the same antibody preincubated with blocking peptide(right).
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Kelian Chen, et,al. (2003) J. Cell Sci ; 117: 4527 - 4536.
Vera Strasser, et,al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386.
Izhar Ben-Shlomo, et,al. (2003) Sci. STKE ; 2003: 9.
H. M. Kim, et,al. (2002) PNAS ; 99: 4020.
If you have published an article using product 21251, please notify us so that we can cite your literature.
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