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Location： Home > Polyclonal Antibodies > CRY1 Antibody

CRY1 Antibody#21414

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Product Detail

Product NameCRY1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAffinity purification

ApplicationsWB,IHC,ELISA

Species ReactivityHuman, Mouse, Rat

SpecificityThe antibody detects endogenous level of total CRY1 protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human CRY1 (NP_004066.1).

Target NameCRY1

ConjugateUnconjugated

Other NamesPHLL1

Accession NoSwiss-Prot: Q16526
NCBI Protein: NP_031797.1

Uniprot Q16526

Gene ID 1407;

Calculated MW66kd

Concentration1.0mg/ml

FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 66kd
Western blotting: 1:500~1:2000

Western blot analysis of extracts from mouse brain tissue using CRY1 antibody #21414.
Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 Antibody #21414.

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.

If you have published an article using product 21414, please notify us so that we can cite your literature.

et al,Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. In Proc Natl Acad Sci U S A on 2013 Mar 19 by Guangsen Shi, Lijuan Xing, et al..PMID: 23471982 , (2013),
PMID: 23471982
et al,Calorie restriction effects on circadian rhythms in gene expression are sex dependent.In Sci Rep on 2017 Aug 29 by Artem A Astafev, Sonal A Patel,et al..PMID: 28851928 , (2017),
PMID: 28851928
et al,Time-restricted Feeding Attenuates High-fat Diet-enhanced Spontaneous Metastasis of Lewis Lung Carcinoma in Mice. In Anticancer Res on 2019 Apr by Lin Yan, Sneha Sundaram, et al..PMID: 30952713 , (2019),
PMID: 30952713
et al,Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction. In Nat Commun on 2022 Jul 9 by Yang An, Baoshi Yuan, et al..PMID: 35810166 , (2022),
PMID: 35810166
et al,Multitissue Circadian Proteome Atlas of WT and Per1-/-/Per2-/- MiceInMol Cell ProteomicsOn2023 DecbyLiujia Qian?1,?Yue Gu et al..PMID: 37940002 , (2023),
PMID: 37940002

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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