Product Detail
Product NameASPSCR1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total ASPSCR1 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.
Target NameASPSCR1
ConjugateUnconjugated
Other NamesASPL; RCC17; TUG; UBXD9; UBXN9
Accession NoSwiss-Prot: Q9BZE9
NCBI Protein: NP_076988.1
Uniprot
Q9BZE9
Gene ID
79058;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 70-75kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from HL60 cells using ASPSCR1 Antibody #21430.
Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.
Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
Bogan, J.S. et al. (2003) Nature 425, 727-33.
Yu, C. et al. (2007) J Biol Chem 282, 7710-22.
If you have published an article using product 21430, please notify us so that we can cite your literature.
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