Product Detail
Product NameVEGFR2(Ab-1059) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu Ms
SpecificityThe antibody detects endogenous levels of total VEGFR2 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa. 1057~1061 (P-D-Y-V-R) derived from Human VEGFR2.
Target NameVEGFR2
ConjugateUnconjugated
Other NamesFLK1; KDR; VGFR2; VGR2; kinase insert domain receptor
Accession NoSwiss-Prot: P35968
NCBI Protein: NP_002244.1
Uniprot
P35968
Gene ID
3791;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 210 230kd
Western blotting: 1:1000
Western blot analysis of cell lysates using VEGFR2(Ab-1059) antibody(#21531) Lane 1 and 2: Huvec cell; Lane 3 HT29 cell)
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Zeng H, et al. (2001) J Biol Chem. 276(35): 32714-32719.
Dougher M, et al. (1999) Oncogene. 18(8): 1619-1627.
If you have published an article using product 21531, please notify us so that we can cite your literature.
et al,Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.In Nat Commun.On 2018 Dec 21 by Liu S, Zhang G et al..PMID: 30575721
, (2018),
PMID:
30575721
Yes
